Heard About Polynucleotides? Here’s An Overview Of How They Work.
Polynucleotides — also known as “salmon DNA” — are the latest buzz in aesthetics. In this article, beauty writer Lucy Abbersteen explains what they are, how they work to boost collagen and hydration, and why these natural biostimulators are redefining skin rejuvenation in 2025.
Aug 8, 2025
By Lucy Abbersteen

If you’re at all tapped into aesthetics, then chances are you’ve heard of polynucleotides or salmon DNA treatments. They’ve been having a huge moment in the tweakment industry over the last few years, and with good reason.
Though more research is needed into what they can achieve, many aesthetic doctors say they are a very promising treatment and attest to their results. Here’s a brief overview of what they are and how they work...
What are polynucleotides?
Polynucleotides are naturally-derived molecules, usually derived from salmon in the context of aesthetic treatments. You may have heard the buzzy nickname “salmon sperm injections” – which, though fun, is a bit of an oversimplification.
Though it’s true that this is their original source, once the DNA fragments have been extracted they’re processed and sterilised before becoming the final product that’s injected into the skin.
They usually require two or three appointments spread out over a period of at least a few weeks, with results lasting around six months – though this of course varies from person to person. As for what they can achieve? Their effects include better elasticity, moisture levels, reduced fine lines and even reduced inflammation in the skin.
How do polynucleotides work?
Polynucleotides are what’s called a biostimulator, which means they stimulate your skin’s collagen and elastin production. They are usually injected into areas like the under-eye area, though can be used in the neck, décolletage and even hands, to help rejuvenate the look of the skin.
They won’t replenish volume, but tend to yield a more “refreshed” appearance by rejuvenating the skin.
What should I do if I want polynucleotides?
An in-person consultation is always the first step to talk through treatments you’re interested in. Remember, if you’re considering any kind of aesthetic treatment, knowledge is power when it comes to successful and safe treatments.
Do your research and ensure you have a consultation with a trusted, qualified professional who has medical training; check their qualifications and insurance, as well as the specific product they use. A consultation also allows you to ask lots of questions before you book – your practitioner may even recommend something else entirely to help you achieve your aesthetic goals, so it’s well worth doing!
By doing your homework you can make sure you feel totally comfortable before undergoing any treatment, but the popularity of polynucleotides doesn’t seem to be wavering any time soon.
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